【Preclude】 means to make impossible or to rule out.

• Her sore throat will 【preclude】 her from singing tonight.

【Prelude】 is an action that acts as an introduction to an event.

• Their actions seemed to be an ironic 【prelude】 to disaster.

【Prelude】 is also a short musical selection that serves to introduce a larger musical selection.

• The orchestra played the 【prelude】 promptly at 8 p.m.

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